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Brian O'Rourke Selected Research

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1/2018Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.
1/2016Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death.

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Brian O'Rourke Research Topics

Disease

21Heart Failure
01/2023 - 02/2002
12Ischemia
09/2023 - 11/2002
6Inflammation (Inflammations)
01/2023 - 10/2003
5Cardiovascular Diseases (Cardiovascular Disease)
05/2022 - 11/2013
5Reperfusion Injury
05/2022 - 03/2004
5Mitochondrial Diseases (Mitochondrial Disease)
10/2019 - 07/2007
4Neoplasms (Cancer)
04/2024 - 08/2010
4Hypertrophy
01/2022 - 12/2008
3Cardiac Sudden Death (Sudden Cardiac Arrest)
10/2023 - 01/2018
3Cardiomyopathies (Cardiomyopathy)
01/2023 - 01/2016
3Obesity
11/2021 - 10/2019
3Insulin Resistance
11/2019 - 10/2015
3Cardiac Arrhythmias (Arrythmia)
03/2015 - 04/2010
3Infarction (Infarctions)
02/2013 - 05/2011
3Myocardial Infarction
11/2012 - 03/2003
2Hyperglycemia
10/2023 - 11/2019
2Ventricular Tachycardia
01/2023 - 04/2010
2Atherosclerosis
05/2022 - 01/2020
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2022 - 02/2010
2Necrosis
01/2021 - 04/2012
2Fibrosis (Cirrhosis)
01/2016 - 06/2014
2Heart Diseases (Heart Disease)
03/2015 - 04/2011
2Hypoxia (Hypoxemia)
06/2011 - 08/2010
2Thrombosis (Thrombus)
01/2005 - 10/2003
1Infections
01/2024
1COVID-19
01/2024
1Atrioventricular Block
01/2024
1Bradycardia
01/2024
1Tachypnea
01/2024
1Alzheimer Disease (Alzheimer's Disease)
01/2023
1Cardiomegaly (Heart Hypertrophy)
05/2022
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2022
1Acute Kidney Injury (Acute Renal Failure)
12/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2021
1Abdominal Obesity
11/2021
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2021
1Fatigue
01/2021
1Flushing
01/2021

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
01/2018 - 02/2002
6Adenosine Triphosphate (ATP)IBA
01/2022 - 11/2002
5PotassiumIBA
09/2023 - 11/2002
5Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 10/2009
4AntioxidantsIBA
01/2024 - 01/2017
4CalciumIBA
01/2020 - 02/2002
4mitochondrial K(ATP) channelIBA
01/2020 - 11/2002
3Mitochondrial DNA (mtDNA)IBA
01/2021 - 01/2020
3KATP ChannelsIBA
01/2020 - 11/2010
3Glucose (Dextrose)FDA LinkGeneric
10/2019 - 10/2015
3Glutathione (Reduced Glutathione)IBA
01/2015 - 11/2008
3NAD (NADH)IBA
12/2013 - 08/2008
3DiamideIBA
04/2010 - 07/2007
2Peptides (Polypeptides)IBA
10/2023 - 01/2021
2Diazoxide (Hyperstat)FDA Link
09/2023 - 03/2003
2Biomarkers (Surrogate Marker)IBA
01/2023 - 01/2023
2Sodium-Calcium ExchangerIBA
01/2023 - 04/2010
2Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
01/2022 - 12/2008
2Phenylephrine (Neo-Synephrine)FDA LinkGeneric
01/2021 - 12/2008
2DNA (Deoxyribonucleic Acid)IBA
01/2020 - 01/2020
2Fatty Acids (Saturated Fatty Acids)IBA
10/2019 - 10/2015
2ProteomeIBA
01/2018 - 01/2016
2SodiumIBA
03/2015 - 08/2004
1Double-Stranded RNA (RNA, Double Stranded)IBA
01/2024
1Poly I-CIBA
01/2024
1CytokinesIBA
01/2024
1Pattern Recognition ReceptorsIBA
01/2024
1InterferonsIBA
01/2024
1Viral ProteinsIBA
01/2024
1mitochondrial calcium uniporterIBA
01/2023
1Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2023
1AngiotensinsIBA
01/2023
1Amyloid (Amyloid Fibrils)IBA
01/2023
1Angiotensin Receptors (Angiotensin II Receptor)IBA
01/2023
1Growth Differentiation Factor 15IBA
01/2023
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
05/2022
1SulfurIBA
05/2022
1Isoproterenol (Isoprenaline)FDA LinkGeneric
01/2022
1Mitochondrial Form Creatine KinaseIBA
01/2022
1Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
01/2022
1Cyclic GMPIBA
11/2021
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
11/2021
1Cyclophilin AIBA
01/2021
1Therapeutic UsesIBA
01/2021
1R 115866IBA
01/2021
1Vitamin A (Retinol)FDA LinkGeneric
01/2021
1Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2021
1RetinoidsIBA
01/2021
1calpastatinIBA
01/2021
1Potassium Channels (Potassium Channel)IBA
01/2020

Therapy/Procedure

11Therapeutics
04/2024 - 03/2009
3Cardiac Resynchronization Therapy
05/2015 - 03/2009
2Ligation
12/2017 - 05/2011
2Drug Therapy (Chemotherapy)
03/2015 - 08/2010
2Lasers (Laser)
01/2015 - 11/2008
1Sympathectomy (Sympathectomies)
10/2023
1Induced Heart Arrest (Cardioplegia)
09/2023
1Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/2023
1Hospice Care (Care, Bereavement)
05/2022
1Immunotherapy
12/2021
1Bioreactors (Bioreactor)
01/2021